البحوث المستمرة

• C/19/430/R: “WNT Activated Medulloblastoma Associated with Metastasis to Suprasellar Region- A case report” N. Ahmad, M. Eltaweel, A Kashgari, A Assiri (published)
• RC/20/353/R: “Impact of COVID-19 on a Tertiary Care Pediatric Oncology and Stem Cell Transplant Unit in Riyadh, Saudi Arabi’, N. Ahmad, M Essa, R Sudairy (published)
• RC20/437/R: “COVID-19 in Pediatric Cancer Patients. How concerned we should be? Lesson learned from a single center in Middle East” N Ahmad, M Eltaweel, W Khan, M Essa T Alharbi, R Sudairy (published)
• RC20/270/R: Para-neoplastic Optic Neuritis Presenting in a Child with Localized Para-testicular Alveolar Rhabdomyosarcoma” N Ahmad, K Gordon(published)
• RC17/022/R: “Wilms tumor – state of affairs in Riyadh, Saudi Arabia. A retrospective review over 15 years from a single center”, N Ahmad, A Khan, A Omari, M Eltaweel Submitted to APJCO in Aug 2020(published)
• Case report: “Orbital Extramedullary relapse in a pediatric patient post CAR-T Cell Therapy-Case report” M Essa, A Alsultan, Published poed. Transplant journal
• RC20/157/R: “Etiology, Management and Outcome of Febrile Neutropenia in a Tertiary Pediatric Oncology Center in Saudi Arabia”, N Ahmad, M Eltaweel, R Abdelateef (on-going)
• RC20/236/R: “Clinico-pathologic profile, management, outcome and treatment related long term complications of pediatric brain tumors in a tertiary care pediatric oncology center in Saudi Arabia - A five year experience” N Ahmad, M Yaqub, K. Jamaan, T. Harbi
• Awaited: “Clinical presentation, adverse prognostic factors and outcome analysis of pediatric bone tumors treated at King Abdullah Specialized Children Hospital, Riyadh, Saudi Arabia - a retrospective review over 20 years” N Ahmad, T Alharbi, A Assiri, R Eleissa & co. (IRB approval Data Collection)
• IRB awaited: “Late Effects of Childhood Cancer and Survivorship issues in Saudi Arabia – a Multicenter Study” S M hasan, N Ahmad, R Sudairy, PSMH and KFSHRC teams
• RC20/496/R: “Impact of Blinatumomab in Children with Acute Lymphoblastic Leukemia: Focus on Outcome and Post Treatment Immunoglobulin Product” M. Essa, R. AlSudairy, R. Abdellatif A. AlOmari, W. Jastaniah
• CT20/021/R (Clinical Trials): A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Voxelotor (GBT440) in Pediatric Participants with Sickle Cell Disease (HOPE Kids 2)”, M Essa, K. Jamaan, Abd. Hammad
• CT19/020/R- CT19/426/R (Clinical Trials): “Genetic Profiling using Next Generation Sequencing to evaluate Mutations Prevalence and Prognostication, in Children Treated for Acute Leukemia in Saudi Arabia.
• A Multicenter SAPHOS Leukemia Group Study” W Ballourah, M. Essa
• RC20/037/R: “Anxiety and Depression among Children with Sickle Cell Disease” R. AlZughaibi, M. Essa, S. Alamri
• RC19/372/R: “Outcome Analysis of translocation t(1;19) in children with acute lymphoblastic leukemia: a study form Saudi Arabia neutropenia in a tertiary pediatric oncology center in Saudi Arabia” M. Essa, Ali alGregri
• RC19/146/R: “Outcome of Stem Cell transplantation in Pediatric patients” M. Essa, A. Alsultan, E. Basher, R. Abujoub
• RC17/306/R: “Antimicrobial prophylaxis and the prevalence of infections in pediatric stem cell transplantation: A single center retrospective study” T. Alrugaib, M. Essa, R. Abujoub E. Basher A. Alsultan
• RC16/214/R: “Prevalence of ALK-positive Neuroblastoma in high risk and relapsed group in Saudi Arabia” M. Essa F. Sufiani Hanan Khormi, Alsultan
• CT17/016/R: “ALL SCTped 2012 FORUM Allogeneic Stem Cell Transplantation in Children and Adolescents with Acute Lymphoblastic Leukemia” M. Essa with international Peters et al
• RC20/446/R (Dr. Essa as sub-PI): “Safety and Feasibility of CD19 Chimeric Antigen Receptor (CAR) T Cells In Adults with CD19 Positive Relapsed and Refractory Acute Lymphoblastic Leukemia or Lymphoma” Bader Alahmari, M. Essa
• RC20/344/R (Dr. Essa as sub-PI): “Epidemiology and Management of Acute emergency Complications in Children with Sickle Cell Disease: The experience of a tertiary hospital in Riyadh, Saudi Arabia” Nesrin Alharthy M. Essa, Residents
• RC19/453/R: Review of Hemophagocytic lymphohistiocytosis: Single institute experience with review of literature” Rasees Alotaibi, M. Essa
• RC17/131/R: “Optimizing Busulfan Dosing and Monitoring in Saudi Children based on Population Pharmacokinetics/Pharmacogenetics” Salman abdullah alfadhel M. Essa
• RC15/043/R Clinical Trials: “HLA-Identical sibling Donor Stem Cell Transplantation for Individuals with Severe Sickle Cell Disease Using a Reduced Intensity Conditioning Regimen”, A. AlSultan, M. Essa
• SP18/108: “The Impact of Total Parenteral Nutrition on Survival Rate, and Complications in Pediatric Stem Cell Transplantation”
• RC16/108/R: “The Use of Complementary and Alternative Medicine among Saudi Children with Cancer: A Cross Sectional Study” by: Dr. Reem Al Sudairy
• RC15/087/R: “The Impact of Childhood Cancer on Families in a Tertiary Care Center, Riyadh, SA” by Dr. Reem Al Sudairy

البحوث المنشورة

• “Improving Door to Antibiotic Administration Time in Patients with Fever and Suspected Chemotherapy Induced Neutropenia: A Tertiary Care Center Experience, Global Journal on Quality and Safety in Healthcare", 2019, DOI, 10.4103/JQSH_1_19, www.jqsh.org (ahead of print) Al Sudairy R, Alzahrani M, Alkaiyat M, Yaqub A, Alfayadh M, Al Surimi K, Jazieh A.
• “Implementing a Communication Model t Enhance Patient-Centered Care. Global Journal on Quality and Patient Safety in Healthcare", 2018. Vol: 1, no.2, pg. 38-43. Jazieh A, Al Sudairy R, Al Shami M, Yaqub A, Al Khesaifi A, Al Dorzi, Al Dorzi H M, Fayad M
• “Clinical characteristics and outcome of childhood acute promyelocitic leukemia, (APL) in Saudi Arabia: A M3ulticenter SAPHOS leukemia group study". Hematology, 2018. Vol. 23, no.6, 316-323 Jastaniah W, Alsutan A, AlDaama, S, Ballourah W, Bayoumy M, Al Anzi F, Al Shareef O, Abrar MB, Al Sudairy R, Al Ghemlas I
• “Clinical characteristics and outcome of childhood acute promyelocitic leukemia, (APL) in Saudi Arabia: A M3ulticenter SAPHOS leukemia group study". Hematology, 2018. Vol. 23, no.6, 316-323, Jastaniah W, Alsutan A, AlDaama, S, Ballourah W, Bayoumy M, Al Anzi F, Al Shareef O, Abrar MB, Al Sudairy R, Al Ghemlas I
• “Identifying Prognostic Factors that Influence Outcome of Childhood Acute Myeloid Leukemia in First Relapse in Saudi Arabia: Results of the Multicenter SAPHOS Study". Clinical Lymphoma, Myeloma & Leukemia, Vol, No. 12, 773-80, 2018. Jastaniah W, Alsutan A, AlDaama, S, Ballourah W, Bayoumy M, Al Anzi F, Al Shareef O, Abrar MB, Al Sudairy R, Al Ghemlas I
• “Quantifying the Howthorne Effect Using Overt and Covert Observation of Hand Hygiene at a Tertiary Care Hospital in Saudi Arabia". Am J Infect Control 2018. In press (accepted 24 February 2018). Dr. El Saied A, Noushad S, Tannous E, Abirizak F, Arabi Y, Al Azzam S, Banyan E, Al-Jahdali H, Al Sudairy R, Balkhy HH:
• “Treatment results in children with Myeloid Leukemia of Down Syndrome in Saudi Arabia: A multicenter SAPHOS leukemia group study". Leukemia Research 2017: 58:48-54 Jastaniah W, Alsultan A, AlDaama, S, Ballourah W, Bayoumy M, Al Anzi F, Al Shareef O, Abrar MB, Al Sudairy R, Al Ghemlas I
• “Clinical Characteristics and Treatment Outcome of Childhood Acute Lymphoblastic Leukemia in Saudi Arabia: A Multi-Institutional Retrospective National Collaborative Study". Pediatr Blood Cancer. 2014 Jan; 61 (1):74-80. Al Sudairy R, Al-Nasser A, Al Sultan A, Al Ahmari A, Abosoudah I, Al Hayek R, Al Harbi T, Al Manjomi F, Al Harbi M, Al Ghamdi H, Al Shahrani M, Belgaumi A,
• “Erlotinib in wild type epidermal growth factor receptor non-small cell lung cancer: A systematic review". Ann Thorac Med.2013 Oct; 8(4); 204-8. Jazieh AR, Al Sudairy R, Abu-shraie N, Al Suwairi W, Ferwana M, Murad MH.
• “Use of Complementary and Alternative Medicine by patients with Cancer in Saudi Arabia". J Altern Compliment Med, 2012 Nov; 18 (11): 1045-9, Jazieh A, Al Sudairy R, Abulkhair O, et al,“Cancer Prevention and Early Detection in Children Malignancies. Pan Arab Journal of Oncology". 2010 March; vol.3; issue 1: 79-83. Al Sudairy R.
• “Improved outcome for children with Acute Lymphoblastic Leukemia after risk-adjusted intensive therapy. A single institution experience". Ann Saudi Med.2008 Jul-Aug; 28(4): 251-259. Al-Nasser A, El-Solh H, De Vol E, El-Hassan I, Al Zahrani A, Al-Sudairy R, Al-Mahar M, Al-Musa A, Al-Jefri A, Saleh M, Rifai S, Belgaumi A, Osman L, Ashraf K, Salim M, Silo A, Roberts G.
• “Papilledema, presenting as reversible loss of vision, in a child with acute lymphoblastic leukemia. Pediatric Blood Cancer". 2005 July; 45(1):72-3. Iqbal Y, Palker V, Al-Sudairy R, Al Omari A, Abdullah MF, Al Debasi T.
• “A lung Mass in a Child". J Ped Hemat/Oncol. 2003 Aug; 25 (8), 677-8, Iqbal Y, Sudairy R, Abdullah F.M., Omari A, Jaddan S.
• “Leukoencephalopathy and Laminar Cortical Necrosis in a Child receiving Intrathecal Methotrexate and Cranial Irradiation". A case report. Ann Saudi Med. May-July 2003; 23 (3-4), 167-170, Iqbal Y, Mah S, Ralkar V, Al Sudairy R, Abdullah M.F., Omari A.
• “Spinal Cord Compression as an Initial Symptom of Childhood". ALL. Ann Saudi Med. May-July 2003; 23 (3-4), 179-180. qbal Y, Sudairy R, Abdullah M, Omari a. Rafaie T.
• “Hepatosplenic Abscesses in Pediatric Oncology Patients receiving Chemotherapy". Six years experience in a single cancer center. Ann Saudi Med 2003; 23 (1-2), 81-86. Iqbal Y, Shalaan M, Sudairy R, Abdullah N, Omari A, Alola S.
• “Non-Hodgkin's Lymphoma manifesting as Thyroid Nodules and Intra Cavity Cardiac Tumor. Prolonged Remission after Chemotherapy". J Ped Hemat/Oncol. 2003; 25 (12), 987-8. Iqbal Y, Sudairy R, Abdullah F, Omari A, Crankson S.
• “Inthratecal Vincristine: Long-Term Survivor of Potentially Fata Chemotherapheutic Error". Ann Saudi Med. 2002; 22 (1-2), 108-09. Iqbal Y, Sudairy R, Abdullah M, Turner C.
• “Rhabdomyosarcoma of the Lung of a Child". A case report and literature review. Ann Saudi 2002; 02 (1-2), 91-3. Iqbal Y. Abdullah m. Jaddan S, Omari A. Tarabichi H, Sudairy R
• “Tissue Plasminogen Activator in Pediatric Occluded Central Venous Catheters". Ann Saudi Med. 2002; 22 (5-6), 300-302. Iqbal Y, Abdel-Malik A, Sudairy R, Abdullah M, Omari A, Crankson S.
• “Bone Marrow Transplantation from Matched Siblings in Patients with Fanconi's Anemia Utilizing Low dose Cyclosphamide, Thoracoabdominal Radiation and Antithymocyte Globulins". Bone Marrow Transplant. 2001 Jan; 27 (2), 139-43. Ayas M. Solh H, Mustafa (Sarhan) M, Mahr M, Al Jefri A, Fawas I, Shalaby L, Al Nasser A, Al Sudairy R.
• “Extramedullary Myeloid Tumors (EMT) in Children. The Limited Value of Local Treatment". J Ped Hemat/Oncol. 2000 Jan-Feb; 22 (1), 34-40. Jenkins D, Al Shabanah M, Al Nasser A, El Solh H, Aur R, Al Sudairy R, Mustafa M, Al Fawas I, Gray A, Martins da Cunha A, Ayas M, Al Mahr M, Kofide A, Mahgoub N, Fifai S, Belgaumi A, Al Jefri A, Al Musa A, Sabbah R.
• “Bone Marrow Transplantation in Children. King Faisal Specialist Hospital Experience. Saudi Journal of Kidney Diseases and Transplantation". 1996; 7 (2), 194-8. Solh H, Al Nasser A, Al Sudairy R.
• “Pediatric Cancer". King Faisal Specialist Hospital and Research Centre Experience. Ann Saudi Med. 1996; 16 (5), 530-3. Al Nasser A, Al Sudairy R, Solh H, Te OB, Michels-Harper DKJ, Sabbah R, Ezzat A.
• “Severe Hypercalcemia in a Child with Relapsed Megakaryoblastic Leukemia". Report of a Case and Review of the Literature. Ann Saudi Med. 1996; 16 (3), 329-31. Al Sudairy R, Al Nasser A, Al Gwaiz l.
• “Adolescent idiopathic scoliosis screening of school girls". Ann Saudi Med. 1992 Nov; 12(6):555-7. Abo-Bakr A, Al-Mazyiad A, Al-Hussein M, Al-Sudairy R, Kimli M, Patel PJ.
• “CAPD in Children in Saudi Arabia". Ann Saudi Med. 1989; 9 (1).
• Noah M, Al Sudairy R. Prevalence of Mitral Valve Prolapse in Healthy Saudi Women. International J Cardio. 1987; 14, 65-9.
• “Total Body Irradiation or Chemotherapy Conditioning in Childhood ALL: A Multinational, Randomized", Noninferiority Phase III Study. J Clin Oncol. 2021;39(4):295-307. doi:10.1200/JCO.20.02529, Peters C, Dalle JH, Locatelli F, et al.
• "Clinical course and outcomes of COVID-19 in hematopoietic cell transplant patients, a regional report from the Middle East" [published online ahead of print, 2021 Apr 27]. Bone Marrow Transplant. 2021;1-8. doi:10.1038/s41409-021-01312-y, El Fakih R, Haroon A, Alfraih F, et al.
• “Lack of transmission of SARS-CoV-2 by platelet transfusion from a COVID-19-positive donor in a hematopoietic stem cell transplantation patient". Pediatr Blood Cancer. 2021;68(2):e28658. doi:10.1002/pbc.28658, Essa MF, Elbashir E, Batarfi K, Alharbi M.
• “Incidence trends of childhood acute lymphoblastic leukemia in Saudi Arabia: Increasing incidence or competing risks?. Cancer Epidemiol. 2020;67:101764. doi:10.1016/j.canep.2020.101764, Jastaniah W, Essa MF, Ballourah W, et al.
• “Frequency of pathogenic/likely pathogenic germline variants in cancer-related genes among children with acute leukemia in Saudi Arabia". Pediatr Blood Cancer. 2020;67(7):e28340. doi:10.1002/pbc.28340, Alsultan A, Essa M, Aljefri A, et al.
• “Orbital extramedullary leukemia relapse in a pediatric patient post-CART cell therapy" Case report [published online ahead of print, 2020 Sep 30]. Pediatr Transplant. 2020;e13852. doi:10.1111/petr.13852, Essa MF, Alsultan A.
• “Population pharmacokinetics of busulfan in Saudi pediatric patients undergoing hematopoietic stem cell transplantation". Int J Clin Pharm. 2020;42(2):703-712. doi:10.1007/s11096-020-00989-3, Alsultan A, Albassam AA, Alturki A, et al.
• “Spectrum of medulloblastoma subtypes and frequency of MYC amplification; Experience from a tertiary care center in Saudi Arabia". Neurosciences (Riyadh). 2020;25(3):218-221. doi:10.17712/nsj.2020.3.20190124, Alassiri AH, Alsufiani FM, Almutairi AA, Almohini IA, Aldosari MA, Essa MF.
• “Successful hematopoietic stem cell transplant in leukocyte adhesion deficiency type III presenting primarily as malignant infantile osteopetrosis". Clin Immunol. 2020 Feb 21:108365. doi: 10.1016/j.clim.2020.108365, Essa MF, Basher E, Alroqi F, Mohammed R, Alsultan A.
• “COVID-19 in Pediatric Cancer Patients: How Concerned We Should Be? Lessons Learned From a Single Center in Middle East"[published online ahead of print, 2020 Nov 11]. J Pediatr Hematol Oncol. 2020;10.1097/MPH.0000000000002013. doi:10.1097/MPH.0000000000002013, Ahmad N, Eltawel M, Khan WM, Essa MF, Alharbi T, Al-Sudairy R.
• “Impact of Covid19 on a tertiary care pediatric oncology and stem cell transplant unit in Riyadh, Saudi Arabia". Pediatr Blood Cancer. 2020;67(9):e28560. doi:10.1002/pbc.28560, Ahmad N, Essa MF, Sudairy R.
• “Veno-occlusive disease after high-dose busulfan-melphalan in neuroblastoma". Bone Marrow Transplant. 2018 Sep 4. doi: 10.1038/s41409-018-0298-y, Schechter T, Perez-Albuerne E, Lin TF, Irwin MS, Essa M, Desai AV, Frangoul H, Yanik G, Dupuis LL, Jacobsohn D, Kletzel M, Ranalli M, Soni S, Seif AE, Grupp S, Dvorak CC.
• “ A pediatric case of Acute Lymophoblastic Leukemia presenting as skull mass". Global Journal of Research Analysis. 2017 11(8:577-578. K. Jamaan “The Impact of Physician-Nurse Communication in Nurses", Satisfaction at Tertiary Referral Hospital Critical Care Unit. International Journal of Scientific Research. 2016 Apr 19;5(1)
• “Low Frequency of ETV6-RUNX (t 12;21) in Saudi Arabian Pediatric Acute Lymphoblastic Leukemia Patients: Association with Clinical Parameters and Early Remission". Asian Pacific Journal of Cancer Prevention. 2015:16 (17):7523-7. K. Jamaan “Perceptions of Nurses on Physician-Nurse Communications at Pediatric Intensive Care Unit". World Journal of Medical Sciences. 2015 12 (4):322-327
• “Studies on Transcranial Doppler Ultrasound Velocities and their Association with Hemoglobin F Expression in Saudi Arabian Pediatric Sickle Cell patients". International Journal of Scientific Research. Accepted for June 2017 Issue. K. Jamaan “Hematopoietic stem cell transplantation in FANCJ/BRIP1 Fanconi anemia" Bone Marrow Transplant. 2016 Nov 21., Alsultan A, Essa M, Alsudairy R.
• “Hematopoietic Stem Cell Transplantation in the Eastern Mediterranean Region (EMRO) 2011-2012: A Comprehensive Report on Behalf of the Eastern Mediterranean Blood and Marrow Transplantation Group (EMBMT)". Hematol Oncol Stem Cell Ther. 2015 Oct 1. Pii: S1658-3876(15)00083-7. doi: 10.1016/j.hemonc.2015.09.002, Dr. Reem Al Sudairy, et. Al.
• “Significant Transplantation-Related Mortality from Respiratory Virus Infections within the First One Hundred Days in Children after Hematopoietic Stem Cell Transplantation". June 24, 2015, Biol Blood Marrow Transplant. 2015 Oct;21(10):1802-7. Dr. Mohammed Essa, et. Al.
• “High Dose Chemotherapy with Autologous Stem Cell Rescued in Saudi Children Less Than 3 years of Age with Embryonal Brain Tumors". J. Pedaitr Hematol Oncol.2015, Dr. Abdulrahman Al Sultan, et. Al.
• “BCL11A enhancer haplotypes and fetal hemoglobin in sickle cell anemia". Blood Cells Mol Dis.2015, Dr. Abdulrahman Al Sultan, et. Al.
• “Regulatory T-cell Deficiency and immune dysregulatio, polyendocrinopathy, enteropathy, X-linked disorder caused by loss-of-function mutations in LRBA". Et Al. J Allergy Clin Immunol. 2015, Dr. Abdulrahman Al Sultan, et. Al.
• “Management of Adolescent Low-Risk Classical Hodgkin Lymphoma: Which Chemotherapy Backbone gives the Best Chance of Omitting Radiotherapy Safely". Journal of Adolescent and Young Adult Oncology Volume X, Number X, 2015, Mary Ann Libert, Inc. DOI: 10.1089/jayao.2015.0038, Ali H. Algiraigri, FRCPC, Mohammed F. Essa, FRCPC “Clinical Characteristics and Genetic Subtypes of Fanconi Anemia in Saudi Patients". Cancer Genetics 209 (2016) 171-176., Yahya Ghazwani, Mohammed Al Balwi, Ibrahim Al-Abdulkareem, Mohammed Al-Drees, Talal Alharbi, Reem Alsudairy, Ali Alomari, Khalid Aljamaan, Mohammed Essa, Mohsen Al-Zahrani, Abdulrahman Alsultan “Clinical Characteristics and Outcome of Childhood de novo Acute Myeloid Leukemia in Saudi Arabia: A Multicenter SAPHOS Leukemia Group Study", Leukemia Research 49 (2016) 66-72, Wasil Jastaniah (Chairman), Ibrahim Al Ghemlas, Saad Al Daama, Walid Ballourah, Mohammad Bayoumy, Faisal Al –Anzi, Omar Al Shareef, Abdulrahman Alsultan, Mohammed Burban Abrar, Reem Al Sudairy “Fludarabine, Antithymocyte Globulin and Low Dose Cyclophosphamide As Conditioning Regimen for Allogeneic Stem Cell Transplantation in Children with Severe Aplastic Anemia", Abstracts/Biol Blood Marrow Transplant 22 (2016) S19-S481, Mohammed F. Essa, Reem Al Sudairy, Sameera Al Afghani, Mohammad Jarrar, Abdulrahman Al Sultan
• “Is the outcome of Childhood Acute Myeloid Leukemia with T (8:21) inferior in Saudi Arabia?" A Multicenter SAPHOS Leukemia Group Study. J Appl Hematol 2017; 8:41-8, Jastaniah W, AlSultan A, AlDaama S, Ballourah W, Bayoumy M, Al Anzi F, Al Shareef O, Abrar MB, Al Sudairy R,Al Ghemlas Deficiency of ADA2 Mimicking Autoimmune Lymphoproliferative Syndrome in the Absence of Livedo Reticularis and Vasculitis" .Pedia Blood and Cancer Journal, Article no. Abdulrahman Alsultan, Enas El Basher, Jubran Qanatish, Majid Al Fadel, Reem Mohammed “Presence of Novel Compound BCR-ABL mutations in late chronic and advanced phase imatinib sensitive CML patients indicates their possible role in CML progression". Cancer Biol and Therapy 2017, Vol.18, no.4,214-221, Afia Muhammad Akram, Zafar Iqbal, Tanveer Akhtar, Ahmed Mukhtar Khalid, Muhammad Farooq Sabar, Mahmood Hussain Qazi, Zeba Aziz, Nadia Sajid, Aamer Aleem, Mahmood Rasool, Muhammad Asif, Saleh Aloraibi, Khaled Al Jamaan, and Mudassar Iqbal.
• “Clinical characteristics and outcome analysis of pediatric B-cell non-Hodgkin's lymphoma. Experience with FAB-LMB 96 and UKCCSG B-cell NHL guidelines in a developing country". Ahmad N, Zaidi A & Badar F et al. Asia Pac J Clin Oncol. 2010 Mar; 6 (1):49-56. doi: 10.1111/j.1743-7563.2009.01264.x